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Article

Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice.

International journal of molecular sciences - 23 Jan 2014

Fernando Viromi, Omura Seiichi, Sato Fumitaka, Kawai Eiichiro, Martinez Nicholas E, Elliott Sadie Faith, Yoh Keigyou, Takahashi Satoru, Tsunoda Ikuo

Abstract excerpt

T helper (Th)2 cells have been proposed to play a neuroprotective role in multiple sclerosis (MS). This is mainly based on "loss-of-function" studies in an animal model for MS, experimental autoimmune encephalomyelitis (EAE), using blocking antibodies against Th2 related cytokines, and knockout mice lacking Th2-related molecules. We tested whether an increase of Th2 responses ("gain-of-function" approach) could...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24463292
DOI: 10.3390/ijms15021700
PMCID: PMC3958817

Genes

GATA3
MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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