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Article

Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2007

Pallandre Jean-René, Brillard Emilie, Créhange Gilles, Radlovic Amandine, Remy-Martin Jean-Paul, Saas Philippe, Rohrlich Pierre-Simon, Pivot Xavier, Ling Xiang, Tiberghien Pierre, Borg Christophe

Abstract excerpt

Immunological tolerance is maintained by specialized subsets of T cells including CD4(+)CD25(+)FOXP3(+) regulatory cells (Treg). Previous studies established that Treg thymic differentiation or peripheral conversion depend on CD28 and Lck signaling. Moreover, foxp3 gene transfer in murine CD4(+)CD25(-) T lymphocytes results in the acquisition of suppressive functions. However, molecular pathways leading to FOXP3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18025205
DOI: 10.4049/jimmunol.179.11.7593

Genes

STAT3
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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