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Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8 + Regulatory T Cells

20 Oct 2022

Abstract excerpt

Background and Objectives Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the CNS. Studies of immune dysfunction in MS have mostly focused on CD4+ Tregs, but the role of CD8+ Tregs remains largely unexplored. We previously evidenced the suppressive properties of rat and human CD8+CD45RClow/neg Tregs from healthy individuals, expressing Forkhead box P3 (FOXP3) and acting through...

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PMID: 36266052
DOI: 10.1212/nxi.0000000000200016

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