Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of KEAP1 and NFE2L2 polymorphisms with temporal lobe epilepsy and drug resistant epilepsy.

Gene - 25 Oct 2015

Liu Zhou, Yin Xiaojian, Liu Lingying, Tao Hua, Zhou Haihong, Ma Guoda, Cui Lili, Li You, Zhang Shuyan, Xu Zhi'en, Yao LiFen, Cai Zhiyou, Zhao Bin, Li Keshen

Abstract excerpt

BACKGROUND AND AIMS: Temporal lobe epilepsy (TLE) is a prevalent form of epilepsy. TLE contributes to the majority of drug resistant epilepsy (DRE) cases and is associated with genetic factors. Kelch-like ECH-associated protein 1 (KEAP1)/Nuclear erythroid 2-related factor 2 (known as NFE2L2 or Nrf2) association has been implicated in neuroprotection due to induction of antioxidant enzymes. The association of one...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Drug Resistant Epilepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy, Temporal Lobe

Share to Genetic Association Studies

Share to Intracellular Signaling Peptides and Proteins

Share to Kelch-Like ECH-Associated Protein 1

Share to NF-E2-Related Factor 2

Share to Young Adult

Source

Identifiers

PMID: 26149655
DOI: 10.1016/j.gene.2015.06.055

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of KEAP1 and NFE2L2 polymorphisms with temporal lobe epilepsy and drug resistant epilepsy.PMID 26149655Read ↗

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease.Semantic proximity Read ↗

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.Semantic proximity Read ↗

Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese.Semantic proximity Read ↗

Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract.Semantic proximity Read ↗

Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsySemantic proximity Read ↗

Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study.Semantic proximity Read ↗

Exploring oxidative stress pathways in epilepsySemantic proximity Read ↗

Genetic association study of the HLA class II alleles DRB1, DQA1, and DQB1 in patients with pharmacoresistant temporal lobe epilepsy associated with mesial hippocampal sclerosis.Semantic proximity Read ↗

Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged ratsSemantic proximity Read ↗

Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsySemantic proximity Read ↗

Patent Review (2017–2020) of the Keap1/Nrf2 Pathway Using PatSeer Pro: Focus on Autoimmune DiseasesSemantic proximity Read ↗

Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.