Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged rats

20 Dec 2024

Abstract excerpt

The use of anesthetics during surgery can cause severe neurological damage and cognitive dysfunction in elderly patients. However, this health issue currently lacks corresponding therapeutic strategies. This research involved the utilization of single-cell RNA sequencing (scRNA-seq) and transcriptomic assessment to pinpoint crucial cell classifications and molecular pathways, as well as the lncRNA expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia and Neurotoxicity Research
Share to Cardiac Ischemia and Reperfusion
Share to Intensive Care Unit Cognitive Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39707048
DOI: 10.1007/s10565-024-09964-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged ratsPMID 39707048Read ↗

Genome-Wide Screen of the Hippocampus in Aged Rats Identifies Mitochondria, Metabolism and Aging Processes Implicated in Sevoflurane AnesthesiaSemantic proximity Read ↗

Whole‐transcriptome sequencing identifies neuroinflammation, metabolism and blood–brain barrier related processes in the hippocampus of aged mice during perioperative periodSemantic proximity Read ↗

RETRACTED: Exploring causative gene and pathway of sevoflurane-induced anesthetic effects and implication on nervous system diseases based on high-throughput scRNA-seq dataSemantic proximity Read ↗

Sevoflurane exposure accelerates the onset of cognitive impairment via promoting p-Drp1S616-mediated mitochondrial fission in a mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Role of Hippocampal Glutamatergic Synaptic Alterations in Sevoflurane‐Induced Cognitive Dysfunction in Aged MiceSemantic proximity Read ↗

Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1.Semantic proximity Read ↗

Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunctionSemantic proximity Read ↗

Normal and Pathological NRF2 Signalling in the Central Nervous SystemSemantic proximity Read ↗

Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorderSemantic proximity Read ↗

Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged miceSemantic proximity Read ↗

A new mechanism of POCD caused by sevoflurane in mice: apoptosis induced by cross-dysfunction of iron and glucose metabolismSemantic proximity Read ↗

Characterization of DNA hydroxymethylation in hypothalamus of elderly mice with postoperative cognitive dysfunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.