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Article

Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract.

Mechanisms of ageing and development - 1 Feb 2010

von Otter Malin, Landgren Sara, Nilsson Staffan, Zetterberg Madeleine, Celojevic Dragana, Bergström Petra, Minthon Lennart, Bogdanovic Nenad, Andreasen Niels, Gustafson Deborah R, Skoog Ingmar, Wallin Anders, Tasa Gunnar, Blennow Kaj, Nilsson Michael, Hammarsten Ola, Zetterberg Henrik

Abstract excerpt

Alzheimer's disease (AD) and age-related cataract, disorders characterized by protein aggregation causing late-onset disease, both involve oxidative stress. We hypothesize that common variants of NFE2L2 and KEAP1, the genes encoding the main regulators of the Nrf2 system, an important defence sys...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20064547
DOI: 10.1016/j.mad.2009.12.007

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20064547-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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