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Article

Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Mar 2014

Bergström Petra, von Otter Malin, Nilsson Staffan, Nilsson Ann-Charloth, Nilsson Michael, Andersen Peter M, Hammarsten Ola, Zetterberg Henrik

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron syndrome influenced by oxidative stress. The transcription factor Nrf2 and its repressor Keap1 constitute an important defence system in cellular protection against oxidative stress. Here we hypothesize that common genetic variations in the genes NFE2L2 and KEAP1, encoding Nrf2 and Keap1, may influence the risk and phenotype of ALS. Five hundred...

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Source

Identifiers

PMID: 24102512
DOI: 10.3109/21678421.2013.839708

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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