Article
Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study.
BMC medical genetics - 12 Dec 2014
von Otter Malin, Bergström Petra, Quattrone Aldo, De Marco Elvira Valeria, Annesi Grazia, Söderkvist Peter, Wettinger Stephanie Bezzina, Drozdzik Marek, Bialecka Monika, Nissbrandt Hans, Klein Christine, Nilsson Michael, Hammarsten Ola, Nilsson Staffan, Zetterberg Henrik
Abstract excerpt
BACKGROUND: The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. Parkinson's disease is a neurodegenerative disease highly associated with oxidative stress. In a previously published study, we reported associations of NFE2L2 haplotypes with risk and age at onset of idiopathic Parkinson's disease in a Swedish discovery material...
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