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Article

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease.

BMC medical genetics - 2 Mar 2010

von Otter Malin, Landgren Sara, Nilsson Staffan, Celojevic Dragana, Bergström Petra, Håkansson Anna, Nissbrandt Hans, Drozdzik Marek, Bialecka Monika, Kurzawski Mateusz, Blennow Kaj, Nilsson Michael, Hammarsten Ola, Zetterberg Henrik

Abstract excerpt

BACKGROUND: Oxidative stress is heavily implicated in the pathogenic process of Parkinson's disease. Varying capacity to detoxify radical oxygen species through induction of phase II antioxidant enzymes in substantia nigra may influence disease risk. Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's...

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Source

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Identifiers

PMID: 20196834
DOI: 10.1186/1471-2350-11-36
PMCID: PMC2843602

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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