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Article

Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202.

Pharmacogenetics and genomics - 1 Sept 2015

Wanga Valentine, Venuto Charles, Morse Gene D, Acosta Edward P, Daar Eric S, Haas David W, Li Chun, Shepherd Bryan E

Abstract excerpt

BACKGROUND: Tenofovir disoproxil fumarate (TDF) causes kidney toxicity in some patients. We carried out genomewide analyses to identify associations with plasma tenofovir clearance and change in creatinine clearance (CrCl) during the first 6 months after initiating therapy among patients randomized to TDF/emtricitabine-containing regimens in AIDS Clinical Trials Group protocol A5202. METHODS: Pharmacokinetic...

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Identifiers

PMID: 26148204
DOI: 10.1097/FPC.0000000000000156
PMCID: PMC4522226

Genes

ABCC4
CLDN10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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