Article
Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients.
BMC infectious diseases - 5 Jun 2017
Salvaggio S E, Giacomelli A, Falvella F S, Oreni M L, Meraviglia P, Atzori C, Clementi E G I, Galli M, Rusconi S
Abstract excerpt
BACKGROUND: Tenofovir (TDF) is one of the most widely used antiretroviral drug. Despite the high degree of tolerability a small percentage of patients experienced alteration in tubular function during TDF use. Intracellular TDF disposition is regulated by ATP-binding cassette (ABC) drug efflux transporters and, a reduced transport activity may be implicated in accumulation of TDF into the cells. The aim of our...
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