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Article

Design and methods of the prevalence and pharmacogenomics of tenofovir nephrotoxicity in HIV-positive adults in south-western Nigeria study.

BMC nephrology - 16 Oct 2020

Hassan Muzamil O, Duarte Raquel, Mabayoje Victor O, Dickens Caroline, Lasisi Akeem O, Naicker Saraladevi

Abstract excerpt

BACKGROUND: Individuals of African descent are at higher risk of developing kidney disease than their European counterparts, and HIV infection is associated with increased risk of nephropathy. Despite a safe renal profile in the clinical trials, long-term use of tenofovir disoproxil fumarate (TDF) has been associated with proximal renal tubulopathy although the underlying mechanisms remain undetermined. We aim to...

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Identifiers

PMID: 33066744
DOI: 10.1186/s12882-020-02082-3
PMCID: PMC7565751

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