Article
A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.
Pharmacogenetics and genomics - 1 Feb 2015
Dahlin Amber, Wittwer Matthias, de la Cruz Melanie, Woo Jonathan M, Bam Rujuta, Scharen-Guivel Valeska, Flaherty John, Ray Adrian S, Cihlar Tomas, Gupta Samir K, Giacomini Kathleen M
Abstract excerpt
BACKGROUND: Tenofovir disoproxil fumarate (TDF) is a widely used antiretroviral agent with favorable efficacy, safety, and tolerability profiles. However, renal adverse events, including the rare Fanconi syndrome (FS), may occur in a small subset of patients treated for HIV infections. OBJECTIVES: The aim of this study was to identify genetic variants that may be associated with TDF-associated FS (TDF-FS)....
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