Article
Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney tubular dysfunction in Japanese patients with HIV-1 infection: a pharmacogenetic study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Dec 2012
Nishijima Takeshi, Komatsu Hirokazu, Higasa Koichiro, Takano Misao, Tsuchiya Kiyoto, Hayashida Tsunefusa, Oka Shinichi, Gatanaga Hiroyuki
Abstract excerpt
BACKGROUND: Tenofovir is a widely used antiretroviral drug although it can cause kidney tubular dysfunction (KTD). The aim of this study was to determine the association between polymorphisms in genes encoding drug transporters and KTD in Japanese patients treated with tenofovir. METHODS: The association between tenofovir-induced KTD and 14 single nucleotide polymorphisms (SNPs) in the ABCC2, ABCC4, ABCC10,...
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