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Article

Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction.

The Journal of infectious diseases - 1 Jul 2011

Pushpakom Sudeep P, Liptrott Neill J, Rodríguez-Nóvoa Sonia, Labarga Pablo, Soriano Vincent, Albalater Marta, Hopper-Borge Elizabeth, Bonora Stefano, Di Perri Giovanni, Back David J, Khoo Saye, Pirmohamed Munir, Owen Andrew

Abstract excerpt

BACKGROUND: Tenofovir (TFV) causes kidney tubular dysfunction (KTD) in some patients, but the mechanism is poorly understood. Genetic variants in TFV transporters are implicated; we explored whether ABCC10 transports TFV and whether ABCC10 single-nucleotide polymorphisms (SNPs) are associated with KTD. METHODS: TFV accumulation was assessed in parental and ABCC10-transfected HEK293 cells (HEK293-ABCC10), CD4(+)...

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Identifiers

PMID: 21628669
DOI: 10.1093/infdis/jir215
PMCID: PMC3105036

Genes

ABCC10

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