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Article

Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila.

Molecular cell - 16 Jul 2015

Reimão-Pinto Madalena M, Ignatova Valentina, Burkard Thomas R, Hung Jui-Hung, Manzenreither Raphael A, Sowemimo Ivica, Herzog Veronika A, Reichholf Brian, Fariña-Lopez Sara, Ameres Stefan L

Abstract excerpt

Uridylation of RNA species represents an emerging theme in post-transcriptional gene regulation. In the microRNA pathway, such modifications regulate small RNA biogenesis and stability in plants, worms, and mammals. Here, we report Tailor, an uridylyltransferase that is required for the majority of 3' end modifications of microRNAs in Drosophila and predominantly targets precursor hairpins. Uridylation modulates...

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Identifiers

PMID: 26145176
DOI: 10.1016/j.molcel.2015.05.033
PMCID: PMC4518039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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