Article
Structure-function analysis of microRNA 3'-end trimming by Nibbler.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2020
Xie Wei, Sowemimo Ivica, Hayashi Rippei, Wang Juncheng, Burkard Thomas R, Brennecke Julius, Ameres Stefan L, Patel Dinshaw J
Abstract excerpt
Nibbler (Nbr) is a 3'-to-5' exoribonuclease whose catalytic 3'-end trimming activity impacts microRNA (miRNA) and PIWI-interacting RNA (piRNA) biogenesis. Here, we report on structural and functional studies to decipher the contributions of Nbr's N-terminal domain (NTD) and exonucleolytic domain (EXO) in miRNA 3'-end trimming. We have solved the crystal structures of the NTD core and EXO domains of Nbr, both in...
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