Article

Unbiased and UMI-informed sequencing of cell-free miRNAs at single-nucleotide resolution

2021-05-04

Abstract excerpt

Terminal nucleotidyl transferases are enzymes that add non-templated nucleotides to RNA molecules. In the case of microRNAs, this process was shown to be functionally relevant for their maturation process and generation of isomiRs with non-canonical mRNA targets. Deconvolution of these posttranscriptional modifications is challenging in particular for extracellular miRNAs that are considered as a target for minima...

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Literature Corpus work: 115d6410-40d6-5f88-9407-aaa3312ded61
DOI: 10.1101/2021.05.04.442244

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