Article

poly(UG)-tailed RNAs in Genome Protection and Epigenetic Inheritance

2019-12-31

Abstract excerpt

Mobile genetic elements threaten genome integrity in all organisms. MUT-2/RDE-3 is a ribonucleotidyltransferase required for transposon silencing and RNA interference (RNAi) in C. elegans . When tethered to RNAs in heterologous expression systems, RDE-3 can add long stretches of alternating non-templated uridine (U) and guanosine (G) ribonucleotides to the 3’ termini of these RNAs (polyUG or pUG tails). Here, we...

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Literature Corpus work: e808f39a-1a07-5c46-a907-919a80668f08
DOI: 10.1101/2019.12.31.891960

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