Article

Identification of rare pseudouridylated microRNA by comprehensive smallRNA bisulfite sequencing of mouse and human tissues

2026-05-15

Abstract excerpt

Pseudouridine (Ψ) is an important post-transcriptional modification of many noncoding RNAs that is under-characterized in microRNA (miRNA) due to historical limitations in pseudouridine mapping methods. Ψ modification stabilizes RNA duplex structures and could therefore play an important role in miRNA target binding and repression. To investigate the extent to which mammalian miRNAs are modified with Ψ, we profile...

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Literature Corpus work: bb633091-449c-5f77-9746-98da7e4b881a
DOI: 10.64898/2026.05.14.725264

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