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Article

Role of NR1I2 (pregnane X receptor) polymorphisms in head and neck squamous cell carcinoma.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Nov 2015

Reuter Tasmin, Warta Rolf, Theile Dirk, Meid Andreas D, Rigalli Juan Pablo, Mogler Carolin, Herpel Esther, Grabe Niels, Lahrmann Bernd, Plinkert Peter K, Herold-Mende Christel, Dyckhoff Gerhard, Haefeli Walter Emil, Weiss Johanna

Abstract excerpt

The pregnane X receptor (PXR) is a transcription factor regulating genes involved not only in pharmacokinetics but also in chemotherapy resistance and cancer progression. The significance of PXR for survival of head and neck squamous cell carcinoma (HNSCC) patients is unknown so far. Single nucleotide polymorphisms (SNPs) in the PXR-encoding NR1I2 gene influence receptor functionality and inducibility by ligands...

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Source

Identifiers

PMID: 26141049
DOI: 10.1007/s00210-015-1150-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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