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Article

Pregnane X receptor polymorphisms associated with human diseases.

Expert opinion on therapeutic targets - 1 Oct 2013

Kotta-Loizou Ioly, Patsouris Efstratios, Theocharis Stamatios

Abstract excerpt

INTRODUCTION: Pregnane X receptor (PXR) belongs to the nuclear hormone receptor superfamily and is mostly expressed in liver and intestine. PXR is activated by a wide range of compounds, including drugs, and regulates the transcription of numerous metabolic enzymes implicated in cellular response to xenobiotics. Genetic variation in the PXR gene may influence a wide range of physiologic pathways and have...

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Identifiers

PMID: 24044545
DOI: 10.1517/14728222.2013.823403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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