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Article

Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment.

Biomolecules - 2 Aug 2021

Skandalaki Aikaterini, Sarantis Panagiotis, Theocharis Stamatios

Abstract excerpt

Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR's regulation. Antineoplastic agents are of particular interest since cancer patients are characterized by significant intra-variability to...

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Identifiers

PMID: 34439808
DOI: 10.3390/biom11081142
PMCID: PMC8394562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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