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Article

PXR variants: the impact on drug metabolism and therapeutic responses

28 Jul 2016

Abstract excerpt

The pregnane X receptor (PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters. Several protein isoforms of PXR exist, and they have differential transcriptional activity upon target genes; transcript variants 3 (PXR3) and 4 (PXR4) do not induce target gene expression, whereas transcript variants 1 (PXR1) and 2 (PXR2) respond to agonist by...

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PMID: 27709012
DOI: 10.1016/j.apsb.2016.07.002

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