Article
Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients.
Clinical pharmacokinetics - 1 Sept 2016
Mbatchi Litaty Céphanoée, Robert Jacques, Ychou Marc, Boyer Jean-Christophe, Del Rio Maguy, Gassiot Matthieu, Thomas Fabienne, Tubiana Nicole, Evrard Alexandre
Abstract excerpt
BACKGROUND AND OBJECTIVES: Nuclear receptors PXR (pregnane X receptor, NR1I2) and CAR (constitutive androstane receptor, NR1I3) are key regulators of irinotecan metabolism, and ligand-dependent modulation of their activity leads to significant drug-drug interactions. Because genetic polymorphisms can also affect the activity of these xenobiotic-sensing receptors, we hypothesized that they could contribute to the...
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