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Article

Identification of NR1I2 genetic variation using resequencing.

European journal of clinical pharmacology - 1 Jun 2007

King Cristi R, Xiao Ming, Yu Jinsheng, Minton Matthew R, Addleman Nicholas J, Van Booven Derek J, Kwok Pui-Yan, McLeod Howard L, Marsh Sharon

Abstract excerpt

OBJECTIVE: The nuclear receptor NR1I2 (also called PXR or SXR) is primarily expressed in mouse and human liver and intestines. Direct activation of NR1I2 occurs in response to a range of xenobiotics, which causes the formation of a heterodimer with the RXR receptor. This heterodimer binds to the nuclear receptor response elements of downstream genes such as ABCB1, CYP2C, and CYP3A. This study determined the...

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Source

Identifiers

PMID: 17404718
DOI: 10.1007/s00228-007-0295-3

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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