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Article

Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.

Archives of toxicology - 1 Jan 2021

Smutny Tomas, Hyrsova Lucie, Braeuning Albert, Ingelman-Sundberg Magnus, Pavek Petr

Abstract excerpt

The pregnane X receptor (PXR, encoded by the NR1I2 gene) is a ligand-regulated transcription factor originally described as a master regulator of xenobiotic detoxification. Later, however, PXR was also shown to interact with endogenous metabolism and to be further associated with various pathological states. This review focuses predominantly on such aspects, currently less covered in literature, as the control of...

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PMID: 33164107
DOI: 10.1007/s00204-020-02916-x

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