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Article

Genetic variations of NR2A1 in Asian populations: implications in pharmacogenetics studies.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Chew Sin Chi, Lim Joanne Siok Liu, Lee Edmund J D, Chowbay Balram

Abstract excerpt

HNF4α (encoded by gene NR2A1) is a dominant transcriptional regulator of various drug disposition genes. It forms a circuitry of molecular cross-talk with other nuclear receptors such as PXR and CAR to synergistically initiate transcription. This study reports on the frequency, linkage disequilibrium pattern and tag-SNP selection of NR2A1 polymorphisms in three local Asian populations, namely Chinese, Malays and...

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PMID: 23268925
DOI: 10.2133/dmpk.dmpk-12-sh-114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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