Article
Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.
Pharmacology - 1 Jan 2008
Wang Xue-Ding, Deng Xiao-Ying, Chen Jie, Li Jia-Li, Chen Xiao, Zhao Li-Zi, Lu Yan, Chowbay Balram, Su Qi-Biao, Huang Min, Zhou Shu-Feng
Abstract excerpt
The pregnane X receptor (PXR/NR1I2) gene is a master regulator for a number of cytochrome P450s (CYPs) and drug transporters. This study aimed to detect the single nucleotide polymorphisms (SNPs) of the PXR gene in Han Chinese (n = 186) and to compare the frequencies of polymorphisms of the PXR gene with those in Caucasian and African Americans reported in the literature. The SNPs of the PXR gene were analyzed...
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