Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional assessment of genetic variants located in the promoter of SHP1 (NR0B2).

Pharmacogenetics and genomics - 1 Nov 2017

Prestin Katharina, Olbert Maria, Hussner Janine, Völzke Henry, Meyer Zu Schwabedissen Henriette E

Abstract excerpt

Small heterodimer partner 1 (SHP1, NR0B2) is a member of the superfamily of nuclear receptors (NRs). Even if this orphan receptor, unlike other NRs, lacks the DNA-binding domain, it is capable of regulating transcription by repressing the activity of other NRs by direct protein-protein interaction. Accordingly, SHP1 is part of negative feedback loops of the transcriptional regulation of genes involved in drug...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inactivation, Metabolic

Share to Kidney

Share to Pharmacogenomic Variants

Share to Promoter Regions, Genetic

Share to Receptors, Cytoplasmic and Nuclear

Share to Transcriptional Activation

Source

Identifiers

PMID: 28873070
DOI: 10.1097/FPC.0000000000000310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional assessment of genetic variants located in the promoter of SHP1 (NR0B2).PMID 28873070Read ↗

Role of nuclear receptor SHP in metabolism and cancer.Semantic proximity Read ↗

The nuclear receptor subfamily 4 group A1 in human diseaseSemantic proximity Read ↗

Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity.Semantic proximity Read ↗

Nuclear receptor variants in liver disease.Semantic proximity Read ↗

Identification of NR1I2 genetic variation using resequencing.Semantic proximity Read ↗

Genetic variations of NR2A1 in Asian populations: implications in pharmacogenetics studies.Semantic proximity Read ↗

A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese.Semantic proximity Read ↗

Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth.Semantic proximity Read ↗

Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.Semantic proximity Read ↗

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.Semantic proximity Read ↗

Nuclear receptor subfamily 5 group A member 2 (NR5A2): role in health and diseasesSemantic proximity Read ↗

Genetic variations of NR1I3 and NR2B1 in Asian populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.