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Article

Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index.

Translational psychiatry - 30 Jun 2015

Clarke T-K, Hall L S, Fernandez-Pujals A M, MacIntyre D J, Thomson P, Hayward C, Smith B H, Padmanabhan S, Hocking L J, Deary I J, Porteous D J, McIntosh A M

Abstract excerpt

Major depressive disorder (MDD) and obesity are frequently co-morbid and this correlation is partly due to genetic factors. Although specific genetic risk variants are associated with body mass index (BMI) and with larger effect sizes in depressed individuals, the genetic overlap and interaction with depression has not been addressed using whole-genome data. Polygenic profile scores for MDD and BMI were created...

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Identifiers

PMID: 26125155
DOI: 10.1038/tp.2015.83
PMCID: PMC4490293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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