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Associations between polygenic risk scores for cardiometabolic phenotypes and adolescent depression and body dissatisfaction.

Pediatric research - 1 Dec 2024

Ekberg Krista M, Michelini Giorgia, Schneider Kristin L, Docherty Anna R, Shabalin Andrey A, Perlman Greg, Kotov Roman, Klein Daniel N, Waszczuk Monika A

Abstract excerpt

BACKGROUND: Adolescents with elevated body mass index (BMI) are at an increased risk for depression and body dissatisfaction. Type 2 diabetes (T2D) is an established risk factor for depression. However, shared genetic risk between cardiometabolic conditions and mental health outcomes remains understudied in youth. METHODS: The current study examined associations between polygenic risk scores (PRS) for BMI and...

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PMID: 38879627
DOI: 10.1038/s41390-024-03323-z

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