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Article

Dissecting shared genetic architecture between depression and body mass index.

BMC medicine - 11 Oct 2024

Zhang Hengyu, Zheng Rui, Yu Binhe, Yu Yuefeng, Luo Xiaomin, Yin Shujuan, Zheng Yingjun, Shi Jie, Ai Sizhi

Abstract excerpt

BACKGROUND: A growing body of evidence supports the comorbidity between depression (DEP) and obesity, yet the genetic mechanisms underlying this association remain unclear. Our study explored the shared genetic architecture and causal associations of DEP with BMI. METHODS: We investigated the multigene overlap and genetic correlation between DEP (N > 1.3 million) and BMI (N = 806,834) based on genome-wide...

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Share to Body Mass Index
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Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Mendelian Randomization Analysis

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 39394142
DOI: 10.1186/s12916-024-03681-9
PMCID: PMC11481102

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