A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder.

doi:10.1186/s12916-015-0334-3

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Article

A genetic risk score combining 32 SNPs is associated with body mass index and improves obesity prediction in people with major depressive disorder.

BMC medicine - 17 Apr 2015

Hung Chi-Fa, Breen Gerome, Czamara Darina, Corre Tanguy, Wolf Christiane, Kloiber Stefan, Bergmann Sven, Craddock Nick, Gill Michael, Holsboer Florian, Jones Lisa, Jones Ian, Korszun Ania, Kutalik Zoltan, Lucae Susanne, Maier Wolfgang, Mors Ole, Owen Michael J, Rice John, Rietschel Marcella, Uher Rudolf, Vollenweider Peter, Waeber Gerard, Craig Ian W, Farmer Anne E, Lewis Cathryn M, Müller-Myhsok Bertram, Preisig Martin, McGuffin Peter, Rivera Margarita

Abstract excerpt

BACKGROUND: Obesity is strongly associated with major depressive disorder (MDD) and various other diseases. Genome-wide association studies have identified multiple risk loci robustly associated with body mass index (BMI). In this study, we aimed to investigate whether a genetic risk score (GRS) combining multiple BMI risk loci might have utility in prediction of obesity in patients with MDD. METHODS: Linear and...

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PMID: 25903154
DOI: 10.1186/s12916-015-0334-3
PMCID: PMC4407390

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