Article

Genetic clusters of BMI reveal symptom-specific causal effects on depression

2025-12-08

Abstract excerpt

<p>While BMI is phenotypically and genetically associated with depression, the extent to which BMI causes depression and the potential causal mechanisms underlying this effect remain unclear. We used PheWAS-based Clustering of Mendelian Randomization instruments (PWC-MR) on 324 BMI-associated SNPs across 407 UK Biobank traits, which identified six genetic clusters. We focused on two well characterised clusters: on...

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Literature Corpus work: 7e7c4ff1-89f7-5fe8-8781-55a4c79afd20
DOI: 10.31234/osf.io/gszuk_v1

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