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Article

Mendelian randomization analysis identified causal Association of Childhood Obesity with adult major depressive disorder.

Pediatric obesity - 1 Dec 2022

Yan Shan-Shan, Xu Qian, Han Bai-Xue, Ni Jing-Jing, Wei Xin-Tong, Feng Gui-Juan, Zhang Hong, Zhang You-Jie, Zhang Lei, Yu Wen-Yuan, Pei Yu-Fang

Abstract excerpt

BACKGROUND: Childhood obesity is associated with adult major depressive disorder (MDD), but their causality is not clear. METHODS: We performed a two-sample Mendelian randomization (MR) analysis to explore the causality of childhood body mass index (BMI) and childhood obesity on MDD, followed by a multivariable MR (MVMR) analysis to investigate the potential role of adult BMI in mediating such effect. We accessed...

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PMID: 35869568
DOI: 10.1111/ijpo.12960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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