Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals.

doi:10.1038/s41398-022-01783-7

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Article

Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals.

Translational psychiatry - 24 Jan 2022

Anguita-Ruiz Augusto, Zarza-Rebollo Juan Antonio, Pérez-Gutiérrez Ana M, Molina Esther, Gutiérrez Blanca, Bellón Juan Ángel, Moreno-Peral Patricia, Conejo-Cerón Sonia, Aiarzagüena Jose María, Ballesta-Rodríguez M Isabel, Fernández Anna, Fernández-Alonso Carmen, Martín-Pérez Carlos, Montón-Franco Carmen, Rodríguez-Bayón Antonina, Torres-Martos Álvaro, López-Isac Elena, Cervilla Jorge, Rivera Margarita

Abstract excerpt

Depression is strongly associated with obesity among other chronic physical diseases. The latest mega- and meta-analysis of genome-wide association studies have identified multiple risk loci robustly associated with depression. In this study, we aimed to investigate whether a genetic-risk score (GRS) combining multiple depression risk single nucleotide polymorphisms (SNPs) might have utility in the prediction of...

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PMID: 35075110
DOI: 10.1038/s41398-022-01783-7
PMCID: PMC8786870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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