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Article

Higher adiposity and mental health: causal inference using Mendelian randomization

14 Jul 2021

Abstract excerpt

Higher adiposity is an established risk factor for psychiatric diseases including depression and anxiety. The associations between adiposity and depression may be explained by the metabolic consequences and/or by the psychosocial impact of higher adiposity. We performed one- and two- sample Mendelian randomization (MR) in up to 145 668 European participants from the UK Biobank to test for a causal effect of...

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PMID: 34270736
DOI: 10.1093/hmg/ddab204

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