Selective expression of Parkinson's disease-relatedLeucine-rich repeat kinase 2G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression

Abstract excerpt

Preferential dysfunction/degeneration of midbrain substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons contributes to the main movement symptoms manifested in Parkinson's disease (PD). Although the Leucine-rich repeat kinase 2 (LRRK2) G2019S missense mutation (LRRK2 G2019S) is the most common causative genetic factor linked to PD, the effects of LRRK2 G2019S on the function and survival of SNpc DA...

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