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Article

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.

The Journal of comparative neurology - 1 Aug 2014

West Andrew B, Cowell Rita M, Daher João P L, Moehle Mark S, Hinkle Kelly M, Melrose Heather L, Standaert David G, Volpicelli-Daley Laura A

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are found in a significant proportion of late-onset Parkinson's disease (PD) patients. Elucidating the neuroanatomical localization of LRRK2 will further define LRRK2 function and the molecular basis of PD. Here, we utilize recently characterized monoclonal antibodies to evaluate LRRK2 expression in rodent brain regions relevant to PD. In both mice and rats, LRRK2...

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Identifiers

PMID: 24633735
DOI: 10.1002/cne.23583
PMCID: PMC4076169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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