Article

Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival

2023-10-10

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD), which is the leading neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). However, whether LRRK2 mutations cause PD and degeneration of DA neurons via a toxic gain-of-function or a loss-of-function mechanism...

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Literature Corpus work: eb2c2ea7-e80b-5774-aca4-56ccf0eb6c68
DOI: 10.1101/2023.10.06.561293

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