Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2015

Villarreal Daniel O, Wise Megan C, Siefert Rebekah J, Yan Jian, Wood Laurence M, Weiner David B

Abstract excerpt

ISG15 is an ubiquitin-like protein induced by type I interferon associated with antiviral activity. ISG15 is also secreted and known to function as an immunomodulatory molecule. However, ISG15's role in influencing the adaptive CD8 T-cell responses has not been studied. Here, we demonstrate the efficacy of ISG15 as a vaccine adjuvant, inducing human papilloma virus (HPV) E7-specific IFNγ responses as well as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Adoptive Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer Vaccines

Share to Immunization

Share to Lymphocyte Depletion

Share to Papillomavirus E7 Proteins

Share to Ubiquitins

Share to Vaccines, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 26122932
DOI: 10.1038/mt.2015.120
PMCID: PMC4817913

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.PMID 26122932Read ↗

Enhancement of HIV-1 Env-Specific CD8 T Cell Responses Using Interferon-Stimulated Gene 15 as an Immune Adjuvant.Semantic proximity Read ↗

Emerging Roles for Immunomodulatory Functions of Free ISG15Semantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

ISG15: A link between innate immune signaling, DNA replication, and genome stabilitySemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroSemantic proximity Read ↗

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read ↗

ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive systemSemantic proximity Read ↗

ISG15 upregulation characterizes a PD-L1-associated immunosuppressive phenotype with CD8+ T-cell dysfunction in hepatocellular carcinoma.Semantic proximity Read ↗

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in MiceSemantic proximity Read ↗

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infectionSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.