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Article

ISG15 upregulation characterizes a PD-L1-associated immunosuppressive phenotype with CD8+ T-cell dysfunction in hepatocellular carcinoma.

International immunopharmacology - 15 Sept 2026

Lv Chao, Liu Tao, Liu Zhenhua, Zhang Yi, Du Jun, Xiao Jingjing

Abstract excerpt

BACKGROUND: Immune checkpoint inhibitors (ICIs) show promise in hepatocellular carcinoma (HCC) treatment, but clinical responses remain limited due to immune evasion. CD8+ T-cell dysfunction is a key mechanism of immune evasion in HCC. Interferon-stimulated gene 15 (ISG15), a ubiquitin-like modifier, is implicated in tumor progression, but its role in immune suppression in HCC is unclear. METHODS: ISG15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42302375
DOI: 10.1016/j.intimp.2026.116992

Genes

ISG15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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