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Article

Many private mutations originate from the first few divisions of a human colorectal adenoma.

The Journal of pathology - 1 Nov 2015

Kang Haeyoun, Salomon Matthew P, Sottoriva Andrea, Zhao Junsong, Toy Morgan, Press Michael F, Curtis Christina, Marjoram Paul, Siegmund Kimberly, Shibata Darryl

Abstract excerpt

Intratumoural mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumour is commonly observed in human tumours. The mechanisms generating such ITH are uncertain. Here we find that ITH can be remarkably well structured by measuring point mutations, chromosome copy numbers, and DNA passenger methylation from opposite sides and individual glands of a 6 cm...

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Share to Adenoma
Share to Cell Division

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

Share to DNA Methylation

Share to Epigenesis, Genetic

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Source

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Identifiers

PMID: 26119426
DOI: 10.1002/path.4581
PMCID: PMC4607608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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