Article
Intra-tumour diversification in colorectal cancer at the single-cell level.
Nature - 1 Apr 2018
Roerink Sophie F, Sasaki Nobuo, Lee-Six Henry, Young Matthew D, Alexandrov Ludmil B, Behjati Sam, Mitchell Thomas J, Grossmann Sebastian, Lightfoot Howard, Egan David A, Pronk Apollo, Smakman Niels, van Gorp Joost, Anderson Elizabeth, Gamble Stephen J, Alder Chris, van de Wetering Marc, Campbell Peter J, Stratton Michael R, Clevers Hans
Abstract excerpt
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and extent of intra-tumour diversification, we characterized organoids derived from multiple single cells from three colorectal cancers as well as from adjacent normal intestinal crypts. Colorectal cancer cells...
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