Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers.

Abstract excerpt

Cancers are clonal expansions, but how a single, transformed human cell grows into a billion-cell tumor is uncertain because serial observations are impractical. Potentially, this history is surreptitiously recorded within genomes that become increasingly numerous, polymorphic, and physically separated after transformation. To correlate physical with epigenetic pairwise distances, small 2,000- to 10,000-cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Count
• Share to Cell Lineage