Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using DNA methylation patterns to infer tumor ancestry.

PloS one - 9 Aug 2010

Hong You Jin, Marjoram Paul, Shibata Darryl, Siegmund Kimberly D

Abstract excerpt

BACKGROUND: Exactly how human tumors grow is uncertain because serial observations are impractical. One approach to reconstruct the histories of individual human cancers is to analyze the current genomic variation between its cells. The greater the variations, on average, the greater the time since the last clonal evolution cycle ("a molecular clock hypothesis"). Here we analyze passenger DNA methylation patterns...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cell Transformation, Neoplastic
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Kinetics

Share to Mitosis

Share to Models, Biological

Source

Open in PubMed Open full text

Identifiers

PMID: 20711251
DOI: 10.1371/journal.pone.0012002
PMCID: PMC2918495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using DNA methylation patterns to infer tumor ancestry.PMID 20711251Read ↗

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers.Semantic proximity Read ↗

Many colorectal cancers are "flat" clonal expansions.Semantic proximity Read ↗

High DNA Methylation Pattern Intratumoral Diversity Implies Weak Selection in Many Human Colorectal CancersSemantic proximity Read ↗

Many private mutations originate from the first few divisions of a human colorectal adenoma.Semantic proximity Read ↗

Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution.Semantic proximity Read ↗

Unraveling the clonal hierarchy of somatic genomic aberrations.Semantic proximity Read ↗

Quantifying cell divisions along evolutionary lineages in cancerSemantic proximity Read ↗

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic dataSemantic proximity Read ↗

Quantifying cell divisions along evolutionary lineages in cancer.Semantic proximity Read ↗

Intra-tumour diversification in colorectal cancer at the single-cell level.Semantic proximity Read ↗

Implications of Epigenetic Drift in Colorectal NeoplasiaSemantic proximity Read ↗

Spatial mutation patterns as markers of early colorectal tumor cell mobility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.