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Article

Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction.

The Journal of pathology - 1 Nov 2015

Chen Yu, Guldiken Nurdan, Spurny Manuela, Mohammed Hawraman H A, Haybaeck Johannes, Pollheimer Marion J, Fickert Peter, Gassler Nikolaus, Jeon Min Kyung, Trautwein Christian, Strnad Pavel

Abstract excerpt

Keratins (K) are cytoprotective proteins and keratin mutations predispose to the development of multiple human diseases. K19 represents the most widely used marker of biliary and hepatic progenitor cells as well as a marker of ductular reaction that constitutes the basic regenerative response to chronic liver injury. In the present study, we investigated the role of K19 in biliary and hepatic progenitor cells and...

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Share to Chemical and Drug Induced Liver Injury
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26108453
DOI: 10.1002/path.4580

Genes

DDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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