Toward unraveling the complexity of simple epithelial keratins in human disease.

doi:10.1172/JCI37762

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Article

Toward unraveling the complexity of simple epithelial keratins in human disease.

The Journal of clinical investigation - 1 Jul 2009

Omary M Bishr, Ku Nam-On, Strnad Pavel, Hanada Shinichiro

Abstract excerpt

Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and include keratin 7 (K7), K8, K18-K20, and K23. Genetically engineered mice that lack SEKs or overexpress mutant SEKs have helped illuminate several keratin functions and served as important disease models. Insight into the contribution of SEKs to human disease has indicated that K8 and K18 are the major constituents of...

Topics

Animals
Biomarkers, Tumor
Humans
Keratins
Liver Diseases
Mice
Mice, Transgenic
Mutation
Neoplasm Metastasis
Neoplasms, Glandular and Epithelial
Proteins

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Identifiers

PMID: 19587454
DOI: 10.1172/JCI37762
PMCID: PMC2701867

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