Article
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.
Proceedings of the National Academy of Sciences of the United States of America - 9 May 2017
Nakagawa Hayato, Suzuki Nobumi, Hirata Yoshihiro, Hikiba Yohko, Hayakawa Yoku, Kinoshita Hiroto, Ihara Sozaburo, Uchino Koji, Nishikawa Yuji, Ijichi Hideaki, Otsuka Motoyuki, Arita Junichi, Sakamoto Yoshihiro, Hasegawa Kiyoshi, Kokudo Norihiro, Tateishi Keisuke, Koike Kazuhiko
Abstract excerpt
The carcinogenic mechanism of extrahepatic cholangiocarcinoma (ECC) is unclear, due at least in part to the lack of an appropriate mouse model. Because human studies have reported frequent genetic alterations in the Ras- and TGFβ/SMAD-signaling pathways in ECC, mice with tamoxifen-inducible, duct-cell-specific Kras activation and a TGFβ receptor type 2 (TGFβR2) deletion were first generated by crossing...
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